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Application and Compatibility of Sulfonamides

Sulfonamides  have been used clinically for decades. They have a broad antibacterial spectrum, definite curative effect, stable properties, easy use, low price, and long-term storage. Today, I will tell you the precautions for sulfonamides. .

by arshine

Sulfonamides  have been used clinically for decades. They have a broad antibacterial spectrum, definite curative effect, stable properties, easy use, low price, and long-term storage. Today, I will tell you the precautions for sulfonamides. .

1. Choose different types of sulfonamides according to the nature of the disease

Systemic infectious diseases: such as sepsis, drugs that are easily absorbed by the intestines, such as cotrimoxazole and sulfadiazine, should be used.

Intestinal infections: such as enteritis and diarrheal diseases, drugs that are not easily absorbed by the intestines, such as sulfamidine, should be used.

Parasitic infection: such as coccidia and leukocyte protozoa infection, sulfamethazine should be used.

Second, according to the nature of sulfonamide drugs to determine the time and dose of medication

The dosage of sulfonamides is divided into shock dosage and maintenance dosage. All assault doses, that is, the first or daily doses, are doubled within the safe range, and then changed to maintenance doses, that is, normal doses.

Combined use with baking soda (sodium bicarbonate): Sulfonamides are easy to crystallize in an acidic environment. If sulfonamide is used alone, when excreted by the kidneys, sulfonamide crystals are easy to separate out and block the ureter, so it should be used in combination with baking soda. prevent crystallization. In addition, sulfonamides should be used with caution or disabled when renal function declines and systemic acidosis occurs.

Combined use with synergist: sulfonamides and synergists (such as TMP) are used together (5:1), and the antibacterial effect is increased by 10 times compared with the simple use.

Combined use with VK and VB family: When sulfonamide drugs are used, they will affect the intestinal absorption of VK and VB family. Therefore, when using sulfonamide drugs, VK and VB should be added to the feed.

Pay attention to the use period of sulfonamides to prevent accumulation of poisoning. Sulfonamides are required to be used in an accurate dose and evenly mixed. The course of treatment is 3 to 5 days, and should not exceed 7 days. Because long-term high-dose use can easily lead to accumulation of poisoning.

3. Precautions for the  sulfonamides uses

Such drugs should not be used for 3 days before and after the vaccine is used, because sulfonamides can inhibit the activity of antigens and reduce the immune effect.

When  sulfonamide drugs  are used externally, such as joint abscesses, the pus, mucus and necrotic tissue should be completely removed from the wound surface, because these substances contain a large amount of para-aminobenzoic acid, which affects the efficacy of sulfonamide drugs.

Pay attention to incompatibility: liquid sulfa drugs such as sulfadiazine sodium injection are not easy to be combined with acidic drugs such as vitamin B, vitamin C, penicillin, tetracycline, ephedrine hydrochloride, etc., otherwise sulfonamide will precipitate. In case of procaine, the curative effect is weakened or even invalid, and in case of calcium oxide and ammonium chloride, it will increase the toxicity to the urinary system.

The dosage of sulfa drugs should be strictly controlled, and the medication should not exceed 7 days, and sufficient drinking water should be supplied at the same time; sulfa compound preparations should be used to reduce the dosage and avoid poisoning, and should be stirred evenly when mixing. For drinking water, 1% to 3% sodium bicarbonate solution can be taken at the same time, and vitamin C and vitamin K can be added to the feed; if poisoning occurs, Shenzhangkang or other kidney detoxification drugs can be used.

The above is an introduction to the precautions and compatibility methods for the use of sulfonamides. I hope it will be helpful to all farming friends. This article is for reference only, if you want to know more about it, please pay attention to us.

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